Interesting question - nothing unusual about a secondary datum being a cylinder (axis). I have to wonder, what industry or application you are accustomed to.
There are two general approaches when defining datum’s on a part or assembly.
1) Datum’s for function: These are those features that facilitate alignment in terms of location, orientation or some combination thereof for a part or assembly in the target assembly.
2) Datum for manufacturing: These are those features that are defined as datum’s because manufacturing considerations outweigh functional requirements of the part or assembly.
In general, we should always define datum’s based on function unless otherwise required.
The order of precedence that we assign to datum’s is normally based on a features relative influence or functional contribution to the parts stability, location or alignment within the target assembly.